Anales de la RANM

205 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 Arturo Fernández-Cruz Pérez An RANM · Año 2019 · número 136 (02) · páginas 201 a 205 EL RELOJ BIOLÓGICO. SU IMPACTO EN LA LONGEVIDAD lessness, suicidal ideation, and substance use. J Youth Adolesc 2015; 44: 362-378. 7. Bargiello TA, Jackson FR, Young MW. Restoration of circadian behavioural rhythms by gene transfer in drosophila. Nature 1984; 312: 752-754. 8. Myers MP, Wager-Smith K, Rothenfluh-Hilfiker A, Young MW. Light-induced degradation of TIMELESS and entrainment of the drosophila circadian clock. Science 1996; 271: 1736-1740. 9. Choogon L, Parikh V, Itsukaichi T, Bae K, Edery I. Resetting the drosophila clock by photic regu- lation of PER and a PER-TIM complex. Science 1996; 271(5256): 1740-1744. 10. Brian K, Price JL, Saez L et al. The drosophila clock gene double-time encodes a protein closely related to human casein kinase Iε. Cell 1998; 94: 97-107. 11. Axelrod S, Saez L, Young MW. Studying circadian rhythm and sleep using genetic screens in dro- sophila. Methods Enzymol 2015; 551: 3-27. 12. Patke A, Murphy PJ, Onat OE et al. Mutation of the human circadian clock gene CRY1 in familial de- layed sleep phase disorder. Cell 2017; 169: 203-215. 13. McAlpine CS, Kiss MG, Rattik S et al. Sleep mod- ulates haematopoiesis and protects against ath- erosclerosis. Nature 2019; 566: 383-387. 14. Lane JM, Jones SE, Dashti HS et al. Biological and clinical insights from genetics of insomnia symp- toms. Nat Genet 2019; 51: 387-393. 15. Kogevinas M, Espinosa A, Castelló A et al. Effect of mistimed eating patterns on breast and pros- tate cancer risk (MCC-Spain Study). Int J Cancer 2018; 143: 2380-2389. 16. Wijnen H, Young MW. The Right period for a Siesta. Neuron 2008; 60: 943-946. 17. Stevens JM, Levine MR, Constantino AE, Motame- di GK. Case of fatal familial imsomnia caused by D178N mutation with phenotypic similarity with Hasihmoto´s encephalopaty. BMJ Case Rep 2018. 18. Domínguez F, Fuster V, Fernández-Alvira JM et al. Association of Sleep Duration and Qual- ity with Subclinical Atherosclerosis. J Am Coll Cardiol 2019; 73: 134-144. 19. Peiyuan Q, Jian J, Zhen L et al. BMAL1 knockout macaque monkeys display reduced sleep and psy- chiatric disorders. Natl Sci Rev 2019; 6: 87-100. 20. Miller LJ, Lu W . These are the world's healthiest nations. https://www.bloomberg.com/news/ar- ticles/2019-02-24/spain-tops-italy-as-world-s- healthiest-nation-while-u-s-slips DECLARACIÓN DE TRANSPARENCIA El autor/a de este artículo declara no tener ningún tipo de conflicto de intereses respecto a lo expuesto en la presente revisión. Si desea citar nuestro artículo: Fernández-Cruz. A. El reloj biológico. Su impacto en la longevidad ANALES RANM [Internet]. Real Academia Nacional de Medicina de España; An RANM · Año 2019 · número 136 (02) · páginas 201– 205 DOI: 10.32440/ar.2019.136.02. rev14