Anales de la RANM

306 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 POLIFENOLES DE LA DIETA Y ENFERMEDADES CARDIOMETABÓLICAS Jara Pérez Jiménez An RANM · Año 2019 · número 136 (03) · páginas 298 a 307 - Avanzar en el estudio de las diferencias interindivi- duales que se encuentran en los ensayos clínicos con polifenoles, es decir, entre sujetos respondedores y no respondedores. Para ello, se deben explorar posibles factores subyacentes en los sujetos, tales como la mi- crobiota basal o modificaciones epigenéticas. - Establecer, tras la superación de todas las limitacio- nes anteriores, recomendaciones de salud pública so- bre la ingesta recomendada de polifenoles, que pue- dan trasladarse al conjunto de la población o a grupos poblacionales específicos. En definitiva, el objetivo fi- nal de las investigaciones sobre polifenoles de la dieta debe ser que estas lleguen a tener una traslación clara a la sociedad. 1. Hu FB, Manson JE, Stampfer MJ et al. 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Proan- thocyanidin content in foods is largely underesti- mated in the literature data: an approach to quan- tification of missing proanthocyanidins. Food Res Int 2009; 42: 1381-1388. 18. Neveu V, Pérez-Jiménez J, Vos F et al. Phenol-Ex- plorer: an online comprehensive database on poly- phenol contents in foods. Database 2010: 1-9. 19. Pérez-Jiménez J, Fezeu L, Touvier M et al. Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr 2011; 93: 1220-1228. 20. Tresserra-Rimbau A, Medina-Remón, Pérez-Jimé- nez J et al. Dietary intake and major food sources of polyphenols in a Spanish population at high cardiovascular risk: the PREDIMED study. Nutr Metab Cardiovasc Dis 2013; 23: 953-959. 21. Nascimento-Souza A, Gontijo de Paiva P, Pérez- Jiménez J . Estimated dietary intake and major food sources of polyphenols in elderly of Viçosa, Brazil: a population-based study. Eur J Nutr 2018; 57: 617-627. 22. Pérez-Jiménez J, Saura-Calixto F. Macromolecular antioxidants or non-extractable polyphenols in fruit and vegetables: intake in four European coun- tries. Food Res Intl 2015; 74: 315-323. 23. Goñi I, Hernández-Galiot A. Intake of nutrient and non-nutrient dietary antioxidants: contribution of macromolecular antioxidant polyphenols in an el- derly mediterranean population. Nutrients 2019; 11(9): 2165. 24. Cardona F, Andrés-Lacueva C, Tulipani S. Benefits of polyphenols on gut microbiota and implications in human health. J Nutr Biochem 2013; 24: 1415-1422. 25. Touriño S, Pérez-Jiménez J, Mateos-Martín M.L et al. Metabolites in contact with the rat digestive tract after ingestion of a phenolic-rich dietary fiber matrix. J Agric Food Chem 2011; 59: 5955-5963. 26. Mateos-Martín ML, Pérez-Jiménez J, Fuguet E et al. Non-extractable proanthocyanidins from grape are a source of bioavailable (epi)catechin and derived metabolites in rats. Br J Nutr 2012; 108: 290-297. 27. Larrosa M, Luceri C, Vivoli E et al. 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