Anales de la RANM

71 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 HIBERNACIÓN Y DISINCRONÍA VENTRICULAR POSTINTERVENCIONISMO Federico Ferrando-Castagnetto An RANM · Año 2020 · número 137 (01) · páginas 65 a 72 de infarto, reducir la isquemia y reclutar miocardio viable. Una intervención percutánea primaria sobre las lesiones no culpables y un inicio más precoz de la terapia antiisquémica, por ejemplo, podrían ser estrategias a considerar. En segundo lugar, las medidas de DMVI obtenidas por diferentes técnicas podrían ser nuevos marcadores pronósticos no invasivos tras un evento coronario agudo. Finalmente, nuestros hallazgos sugieren que el umbral óptimo de captación utilizado para cuantificar el miocardio viable mediante gated-SPECT debería ser reconsiderado. En la enfermedad coronaria residual postintervencio- nismo existe una estrecha correlación entre la cuantía del miocardio hibernado y los índices de disincronía obtenidos por AF. La mejor correlación se observa al utilizar un umbral de captación miocárdica basal de 40%, especialmente cuando existe tejido cicatrizal asociado al miocardio hibernado. Una evaluacion individualizada y multimodal de la DMVI asociada al miocardio viable podria ahondar el conocimiento sobre la dinámica contráctil asociada a diferentes estados metabólicos miocárdicos y, quizás, aportar a la difícil toma de decisiones clínicas en la coronario- patía crónica. 1. Torrent-Guasp F. Structure and function of the heart. Rev Esp Cardiol 1998;51:91-102. 2. Helm P, Beg MF, Miller MI, et al. Measuring and mapping cardiac fiber and laminar architecture using diffusion tensor MR imaging. Ann NY Acad Sci 2005;1047:296-307. 3. Bogaert J, Rademakers FE. Regional nonunifor- mity of normal adult human left ventricle. Am J Physiol Heart Circ Physiol 2001;280:H610-20. 4. Abraham WT, Fisher WG, Smith AL, et al; MI- RACLE Study Group. Cardiac resynchroni- zation in chronic heart failure. N Engl J Med 2002;346:1845-1853. 5. Rahimtoola SH. The hibernating myocardium. Am Heart J 1989;117:211-221. 6. Adelstein EC, Saba S. Scar burden by myocar- dial perfusion imaging predicts echocardiogra- phic response to cardiac resynchronization the- rapy in ischemic cardiomyopathy. Am Heart J 2007;153:105-112. 7. Brandão SCS, Nishioka SAD, Giorgi MCP, et al. Cardiac resynchronization therapy evaluated by myocardial scintigraphy with 99mTc-MIBI: changes in left ventricular uptake, dyssynchrony and function. Eur J Nucl Med Mol Imaging 2009;36:986-996. 8. Trimble M, Borges-Neto S, Honeycutt E, et al. Evaluation of mechanical dyssynchrony and myo- cardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. J Nucl Cardiol 2008;15:663-670. 9. Al Jaroudi W, Chen J, Jaber WA, et al. Non-echo- cardiographic imaging in evaluation for cardiac resynchronization therapy. Circ Cardiovasc Ima- ging 2011;4:334-343. 10. Ypenburg C, Schalij M, Bleeker G, et al. Extent of viability to predict response to cardiac resyn- chronization therapy in ischemic heart failure pa- tients. J Nucl Med 2006;47:1565-1570. 11. Chen J, Garcia EV, Folks RD, et al. Onset of left ventricular mechanical contraction as determi- ned by phase analysis of ECG-gated myocardial perfusion SPECT imaging: development of a diag- nostic tool for assessment of cardiac mechanical dyssynchrony. J Nucl Cardiol 2005;12:687-695. 12. Zhang F, Yang W, Wang Y, et al. Is there an asso- ciation between hibernating myocardium and left ventricular mechanical dyssynchrony in patients with myocardial infarction? Hell J Nucl Med 2018;21:28-34. 13. Binder A, Ali A, Chawla R, et al. Myocardial pro- tection from ischemia-reperfusion injury post co- ronary revascularization. Expert Rev Cardiovasc Ther 2015;13:1045-1057. 14. Alfonso F, García P, Pimentel G, et al.; Intravascu- lar ultrasound study. Predictors and implications of residual plaque burden after coronary stenting: an intravascular ultrasound study. Am Heart J 2003;145:254-261. 15. Maruskova M, Gregor P, Bartunek J, et al. Myo- cardial viability and cardiac dyssynchrony as strong predictors of perioperative mortality in high-risk patients with ischemic cardiomyopathy having coronary artery bypass surgery. J Thorac Cardiovasc Surg 2009;138:62-68. 16. Bleeker GB, Kaandorp TA, Lamb HJ, et al. Effect of posterolateral scar tissue on clini- cal and echocardiographic improvement after cardiac resynchronization therapy. Circulation 2006;113:969-976. 17. Sciagra R, Giaccardi M, Porciani MC, et al. Myocardial perfusion imaging using gated SPECT in heart failure patients undergoing cardiac resynchronization therapy. J Nucl Med 2003;45:164-168. 18. Bilchick KC, Dimaano V, Wu KC, et al. Cardiac magnetic resonance assessment of dyssynchrony and myocardial scar predicts function class im- provement following cardiac resynchronization therapy. J Am Coll Cardiol 2008;1:561-568. 19. Leyva F, Foley PWX, Stegemann B, et al. Develo- pment and validation of a clinical index to predict survival after cardiac resynchronisation therapy. Heart 2009;95:1619-1625. 20. Bax JJ, van der Wall EE, Harbinson M. Radionu- clide techniques for the assessment of myocardial viability and hibernation. Heart 2004; 90(Suppl. V):V26-V33. 21. Tajoury TH, Chareonthaitawee P. Myocardial vi- ability imaging and revascularization in chronic ischemic left ventricular dysfunction. Expert Rev Cardiovasc Ther 2010;8:55-63. 22. Allman KC, Shaw LJ, Hachamovitch R, et al. Myocardial viability testing and impact of revas- cularization on prognosis in patients with coro- nary artery disease and left ventricular systolic dysfunction: a meta-analysis. J Am Coll Cardiol 2002;39:1151-1158. BIBLIOGRAFÍA CONCLUSIONES

RkJQdWJsaXNoZXIy ODI4MTE=