Anales de la RANM

219 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 Pedro Jaén-Olasolo An RANM · Año 2020 · número 137 (02) · páginas 213 a 221 MANIFESTACIONES CUTÁNEAS DE LA COVID-19 Se desconoce la incidencia real de manifestaciones cutáneas asociadas a la COVID-19. Se han estudiado principalmente las manifestaciones producidas en pacientes hospitalizados. La incidencia y caracte- rísticas de estas manifestaciones en pacientes asintomáticos podría variar respecto a los datos publicados. Si bien no se ha demostrado que las manifesta- ciones cutáneas alteren el curso de la enfermedad, es importante conocerlas para poder identificar aquellos casos asintomáticos o paucisintomáticos, evitando la propagación del virus. Aún queda por describir si existen factores pronósticos asociados a estas manifestaciones o si existen variaciones en la carga viral de estos pacientes. En conclusión, las características morfológicas de las manifestaciones cutáneas asociadas a la COVID-19 han sido exhaustivamente descritas y categorizadas. Sin embargo, aún falta por definir con claridad la fisiopatología de las mismas. Conocer de manera exhaustiva las vías molecu- lares implicadas en la patogénesis de estas lesiones podría tener aplicaciones tanto pronósticas como terapéuticas. 1. Russell B, Moss C, Rigg A, Hopkins C, Papa S, Van Hemelrijck M. Anosmia and ageusia are emerging as symptoms in patients with CO- VID-19: what does the current evidence say? Ecancer. 2020; 14: ed98. 2. Bai Y, Yao L, Wei T, Tian F, Jin D-Y, Chen L, et al. Presumed asymptomatic carrier transmission of COVID-19. JAMA. 2020; 323(14): 1406-1407. 3. Zhou M, Zhang X, Qu J. Coronavirus disease 2019 (COVID-19): a clinical update. Front Med. 2020; 14(2): 126-135. 4. Liu Y, Gayle AA, Wilder-Smith A, Rocklöv J. The reproductive number of COVID-19 is higher compared to SARS coronavirus. J Travel Med. 2020; 27(2). doi: 10.1093/jtm/taaa021. 5. Guan W, Ni Z, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. 2020; 382(18): 1708-1720. 6. Elston DM. Occupational skin disease among health care workers during the coronavirus (CO- VID-19) epidemic. J Am Acad Dermatol. 2020; 82(5): 1085-1086. 7. Yan Y, Chen H, Chen L, Cheng B, Diao P, Dong L, et al. Consensus of Chinese experts on pro- tection of skin and mucous membrane barrier for health-care workers fighting against corona- virus disease 2019. Dermatol Ther. 2020; 33(4): e13310. https://doi.org/10.1111/dth.13310 8. Recalcati S. Cutaneous manifestations in CO- VID-19: a first perspective. J Eur Acad Dermatol Venereol . 2020;34(5): e212-e213. 9. Piccolo V, Neri I, Filippeschi C, Oranges T, Ar- genziano G, Battarra VC, et al. Chilblain-like le- sions during COVID-19 epidemic: a preliminary study on 63 patients. J Eur Acad Dermatol Vene- reol. 2020; 34(7):e291-e293. 10. Estébanez A, Pérez-Santiago L, Silva E, Guillen- Climent S, García-Vázquez A, Ramón MD. Cuta- neous manifestations in COVID-19: a new con- tribution. J Eur Acad Dermatol Venereol. 2020; 34(6): e250-e251. 11. Fernández-Nieto D, Ortega-Quijano D, Segu- rado-Miravalles G, Pindado-Ortega C, Prieto- Barrios M, Jiménez-Cauhe J. Comment on: cu- taneous manifestations in COVID-19: a first perspective: safety concerns of clinical images and skin biopsies. J Eur Acad Dermatol Vene- reol. 2020; 34(6): e252-e254. 12. Kampf G, Todt D, Pfaender S, Steinmann E. Per- sistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. J Hosp Infect. 2020; 104(3): 246-251. 13. Chesser H, Chambliss JM, Zwemer E. Acute hemorrhagic edema of infancy after coronavirus infection with recurrent rash. Case Rep Pediatr. 2017. doi:10.1155/2017/5637503 14. Galván Casas C, Català A, Carretero Hernández G et al. Classification of the cutaneous mani- festations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases. Br J Dermatol. 2020; 183: 71-77. 15. De Masson A, Bouaziz J-D, Sulimovic L et al. Chilblains is a common cutaneous finding dur- ing the COVID-19 pandemic: a retrospective na- tionwide study from France. J Am Acad Derma- tol. 2020; 83(2): 667-670. 16. Fernández-Nieto D, Jiménez-Cauhe J, Suárez- Valle A et al. Characterization of acute acral skin lesions in nonhospitalized patients: a case series of 132 patients during the COVID-19 outbreak. J Am Acad Dermatol. 2020; 83(1): e61-e63. 17. Landa N, Mendieta-Eckert M, Fonda-Pascual P, Aguirre T. Chilblain-like lesions on feet and hands during the COVID-19 pandemic. Int J Dermatol. 2020; 59(6):739-743. 18. Andina D, Noguera‐Morel L, Bascuas‐Arribas M, et al. Chilblains in children in the setting of COVID‐19 pandemic. Pediatr Dermatol. 2020; 37(3): 406-411. 19. Ruggiero G, Arcangeli F, Lotti T et al. Reply to: Characterization of acute acro-ischemic lesions in non-hospitalized patients: a case series of 132 patients during the COVID-19 outbreak. J Am Acad Dermatol. 2020; 83(3): e237-e239. 20. Zhang Y, Cao W, Xiao M et al. [Clinical and coag- ulation characteristics of 7 patients with critical COVID-2019 pneumonia and acro-ischemia]. Zhonghua Xue Ye Xue Za Zhi. 2020; 41(0): E006. doi:10.3760/cma.j.issn.0253-2727.2020.0006 21. Fernández-Nieto D, Jiménez-Cauhe J, Suárez- Valle A et al. Comment on: Acral findings during the COVID-19 outbreak: chilblain-like lesions should be preferred to acroischemic le- sions. J Am Acad Dermatol. 2020; 83(3): e233- e234. 22. McKechnie JL, Blish CA. The innate immune system: fighting on the front lines or fanning the flames of COVID-19? Cell Host Microbe. 2020; 27(6): 863-869. 23. Kolivras A, Dehavay F, Delplace D et al. Corona- virus (COVID-19) infection-induced chilblains: BIBLIOGRAFÍA