Anales de la RANM

229 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 OBESIDADES INFANTILES Y MEDICINA DE PRECISIÓN Martos-Moreno GA, et al. An RANM. 2021;138(03): 221 - 230 Centro Cochrane Iberoamericano, coordinador. Guía de práctica clínica sobre la prevención y el tratamiento de la obesidad infantojuvenil. Ma- drid: Plan de Calidad para el Sistema Nacional de Salud del Ministerio de Sanidad y Política Social. Agència d´Avaluació de Tecnologia i Recerca Mè- diques; 2009. Guía de práctica clínica: AATRM N.º 2007/25. (Actualización 2013 disponible en: The validity of recommendations from clinical guideli- nes: a survival analysis. CMAJ 2014; 186: 1211-9). DOI: 10.1503/cmaj.140547. 4. Martos-Moreno GÁ, Barrios V, Chowen JA, Argen- te J. Adipokines in childhood obesity. Vitam Horm. 2013; 91:107-42. DOI: 10.1016/B978-0-12-407766- 9.00006-7. 5. Serra Majem L, Ribas Barba L, Aranceta Bartrina J, Perez Rodrigo C, Saavedra Santana P, Pena Quin- tana L. Childhood and adolescent obesity in Spain. Results of the enKid study (1998-2000). Med Clin (Barc) 2003; 121: 725-32. DOI: 10.1016/s0025- 7753(03)74077-9. 6. Ministerio de Sanidad, Política Social e Igualdad. Estudio de prevalencia de obesidad infantil «Aladi- no». [Consultado 07 diciembre 2019]. Disponible en: http://www.aecosan.msssi.gob.es/AECOSAN/ docs/documentos/nutricion/observatorio/estu- dio_ALADINO_2011.pdf 7. Miqueleiz E, Lostao L, Ortega P, Santos JM, As- tasio P, Regidor E. Trends in the prevalence of childhood overweight and obesity according to socioeconomic status: Spain, 1987-2007. Eur J Clin Nutr. 2014; 68(2):209–14. DOI: 10.1038/ ejcn.2013.255. 8. Instituto Nacional de Estadística (INE). Encuesta Nacional de Salud 2017 [Consultado 06 noviem- bre 2021]. Disponible en: https://www.mscbs. gob.es/estadEstudios/estadisticas/encuestaNacio- nal/encuestaNac2017/ ENSE17_pres_web.pdf. 9. Bouchard C, Tremblay A, Després JP, et al. The res- ponse to long-term overfeeding in identical twins. N Engl J Med 1994; 322: b1477-82. DOI: 10.1056/ NEJM199005243222101. 10. Khera AV, Chaffin M, Wade KH, et al. Polygenic Prediction of Weight and Obesity Trajectories from Birth to Adulthood. Cell 2019; 177: 587-596.e9. DOI: 10.1016/j.cell.2019.03.028. DOI: 10.1016/j. cell.2019.03.028. 11. Godfrey KM, Reynolds RM, Prescott SL, Nyirenda M, Jaddoe VWV, Eriksson JG, et al. Influence of maternal obesity on the long-term health of offs- pring. Lancet Diabetes Endocrinol 2017; 5: 53–64. DOI: 10.1016/S2213-8587(16)30107-3. 12. Bochukova EG, Huang N, Keogh J, et al. Large, rare chromosomal deletions associated with severe early-onset obesity. Nature 2010; 463: 666-70. DOI: 10.1038/nature08727. 13. Martos-Moreno GÁ, Serra-Juhé C, Pérez-Jurado LA, Argente J. Underdiagnosed Beckwith-Wie- demann syndrome among early onset obese chil- dren. Arch Dis Child. 2014; 99: 965-967. DOI: 10.1136/archdischild-2014-307097. 14. Hofker M, Wijmenga C. A supersized list of obesity genes. Nat Genet 2009; 41:139-140. DOI: 10.1038/ ng0209-139. 15. Martos-Moreno GÁ, Argente J. Obesidades em la infância. Pediatr Integral 2020; XXIV: 220 – 230. 16. Coll AP, Farooqi IS, O’Rahilly S. The hormonal control of food intake. Cell 2007; 129:251–262. DOI: 10.1016/j.cell.2007.04.001. 17. Yang Y, van der Klaauw AA, Zhu L, et al. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Com- mun 2019; 10:1718. DOI: 10.1038/s41467-019- 08737-6. 18. Bonnefond A, Raimondo A, Stutzmann F, et al. Loss-of-function mutations in SIM1 contribute to obesity and Prader-Willi-like features. J Clin Invest 201; 123: 3037-41. DOI: 10.1172/JCI68035. 19. Martos-Moreno GÁ, Martínez-Villanueva J, Gon- zález-Leal R, Chowen JA, Argente J. Sex, Puberty, and Ethnicity Have a Strong Influence on Growth and Metabolic Comorbidities in Children and Adolescents With Obesity: Report on 1300 Pa- tients (The Madrid Cohort). Pediatr Obes 2019; 14: e12565. DOI: 10.1111/ijpo.12565. 20. Klish, WJ. Clinical evaluation of the obe- se child and adolescent. Up to date (revisión bibliográfica hasta enero 2021). Disponi- ble en: https://www.uptodate.com/contents/ clinical-evaluation-of-the-obese-child-and- adolescent?source=related_link. 21. Zimmet P, Alberti KG, Kaufman F, et al; IDF Con- sensus Group. The metabolic syndrome in children and adolescents – an IDF consensus report. Pedia- tr Diabetes 2007; 8: 299-306. DOI: 10.1111/j.1399- 5448.2007.00271.x. 22. Martos-Moreno GÁ, Martínez-Villanueva Fer- nández J, Frías-Herrero A, et al. Conservative Treatment for Childhood and Adolescent Obesity: Real World Follow-Up Profiling and Clinical Evo- lution in 1300 Patients. Nutrients 2021, 13, 3847; https://DOI.org/10.3390/nu13113847. 23. Martos-Moreno GÁ, Martínez-Villanueva J, Gon- zález-Leal R, et al. Ethnicity Strongly Influences Body Fat Distribution Determining Serum Adipo- kine Profile and Metabolic Derangement in Child- hood Obesity. Front Pediatr 2020; 8: 551103. DOI: 10.3389/fped.2020.551103. eCollection 2020. 24. Styne DM, Arslanian SA, Connor EL, et al. Pedia- tric Obesity—Assessment, Treatment, and Preven- tion: An Endocrine Society Clinical Practice Gui- deline. J Clin Endocrinol Metab 2017; 102: 1–49. DOI: 10.1210/jc.2016-2573. 25. Holmgren A, Martos-Moreno GÁ, Niklasson A, et al. The pubertal growth spurt is diminished in children with severe obesity. Pediatr Res 2021; 90: 184-190. DOI: 10.1038/s41390-020-01234-3. 26. Kleinendorst L, Abawi O, van der Voorn B, et al. Identifying underlying medical causes of pediatric obesity: Results of a systematic diagnostic approach in a pediatric obesity center. PLoS One 2020; 15: e0232990. DOI: 10.1371/journal.pone.0232990. eCollection 2020. 27. Martos-Moreno GÁ, Serra-Juhé C, Pérez-Jurado LA, et al. Aspectos genéticos de la obesidad. Rev Esp Endocrinol Pediatr 2017;8 Suppl(1): 21-32. DOI: 10.3266/RevEspEndocrinolPediatr.pre2017. Apr.391 28. Kelly AS, Auerbach P, Barrientos-Perez M, et al; NN8022-4180 Trial Investigators. A Randomized, Controlled Trial of Liraglutide for Adolescents with Obesity. N Engl J Med 2020; 382: 2117-2128. DOI: 10.1056/NEJMoa1916038.