Anales de la RANM

62 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 SERUM MYELOPEROXIDASE AND PARKINSON´S DISEASE Fernández-Espejo E An RANM. 2022;139(01): 56 - 66 putamen vs. Hoehn-Yahr scale, p<.005; vs. motor MDS-UPDRS part III, p<.005), as shown in Table 3 and Figure 3. Percentage reduction of DAT binding on the caudate nucleus did not significantly correlate with rating scales of motor severity. Taken together, these results indicate that the degree of loss of striatal dopaminergic neuronal terminals, as evaluated with DAT-SPECT, is well quantified with rating scales of motor severity that are commonly used in the clinics. Figure 2. Correlation values between serum MPO concentration and percentage reduction of specific binding ratio or %rSBR on basal ganglia in patients with idiopathic Parkinson’s disease. Significant correlation was found between serum MPO con- centration and percentage reduction of SBR or %rSBR on basal ganglia (all p<.0005). Abbrev.: CSF, cerebrospinal fluid; MPO, myeloperoxidase; MDS-UPDRS, International Parkinson and Movement Disorder Society-Sponsored revision of the Unified Parkinson’s Disease Rating Scale; SBR, specific binding ratio; %rSBR, percentage reduction of SBR. Figure 3. Correlation values between percentage reduction of specific binding ratio on basal ganglia (%rSBR), and rating scales of disease severity (Hoehn-Yahr scale, motor MDS-UPDRS part III) in patients with idiopathic Parkinson’s disease. Percentage reduction of DAT binding on the striatum and putamen positively correlated with rating scales of motor severity (right and left striatum, and right and left putamen vs. Hoehn-Yahr scale, p<.005, motor MDS-UPDRS part III, p<.005). Ab- brev.: MDS-UPDRS, International Parkinson and Movement Disorder Society-Sponsored revision of the Unified Parkinson’s Disease Rating Scale; SBR, specific binding ratio; %rSBR, percentage reduction of SBR.