Anales de la RANM

63 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 SERUM MYELOPEROXIDASE AND PARKINSON´S DISEASE Fernández-Espejo E An RANM. 2022;139(01): 56 - 66 Table 3.- Correlation of serum and CSF MPO concentration with demographic, clinical and DAT-SPECT pa- rameters, and correlation of rating scales of disease severity with percentage reduction of specific binding ratio, in patients with idiopathic Parkinson’s disease Serum P CSF P MPO concentration and demographic and clinical parameters Age, years .212 NS -.168 NS Gender .189 NS .202 NS Levodopa equivalent daily dose, mg .137 NS -.133 NS Disease duration, years .361 NS .262 NS Age at PD onset, years .022 NS .-.126 NS Hoehn and Yahr stage .571 =.0003 .212 NS Total MDS-UPDRS (I-III) (on) .399 NS .073 NS MDS-UPDRS part III (on) .458 =.005 .081 NS MDS-UPDRS part IV (all patients) .128 NS .173 NS MPO concentration and %rSBR on basal ganglia Right striatum .678 <.0001 -.162 NS Left striatum .687 <.0001 .027 NS Right caudate nucleus .636 <.0001 -.191 NS Left caudate nucleus .589 =.0002 -.218 NS Right putamen .658 <.0001 -.125 NS Left putamen .606 <.0001 -.019 NS Rating scales of disease severity and %rSBR on basal ganglia Hoehn and Yahr scale (P) Total MDS-UPDRS (P) MSD-UPDRS part III (P) MSD-UPDRS part IV (P) Right striatum .561 (=.0003) .374 (NS) .459 (=.005) -.045 (NS) Left striatum .656 (<.0001) .427 (NS) .462 (=.0046) .016 (NS) Right caudate nucleus .390 (NS) .263 (NS) .306 (NS) -.080 (NS) Left caudate nucleus .382 (NS) .233 (NS) .294 (NS) -.176 (NS) Right putamen .452 (=.005) .342 (NS) .471 (=.0037) -.039 (NS) Left putamen .478 (=.00036) .414 (NS) .531 (=.0009) .134 (NS) Mean ± SD. Statistical correlation was carried out with the Pearson´s test, and Bonferroni correction. Percentage reduction of dopamine-transporter binding on basal ganglia was quantified through the specific binding ratio of the radioligand 123I-Io- flupane. The size of the patients´ cohort was 36. Abbrev.: PD, Parkinson’s disease; MPO, myeloperoxidase; NS, no significant; CSF, cerebrospinal fluid; DAT-SPECT, Dopamine-transporter Single Photon Emission Computed Tomography; MDS-UPDRS, International Parkinson and Movement Disorder Society-Sponsored revision of the Unified Parkinson’s Disease Rating Scale; P, two-tailed probability value; %rSBR, percentage reduction of specific binding ratio.