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87 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 AMYOTROPHIC LATERAL SCLEROSIS IS NOT ONLY A MOTOR NEURON DISEASE Fernández A, et al. An RANM. 2022;139(01): 78 - 87 44. Ruiz-Ruiz C, Calzaferri F, García AG. P2X7 Receptor antagonism as a potential therapy in amyotrophic lateral sclerosis. Front Mol Neu- rosci. 2020; 13: 93. 45. DiSabato DJ, Quan N, Godbout JP. Neuroin- flammation: the devil is in the details. J Neu- rochem. 2016; 139(Suppl 2): 136-153. 46. Gandelman M, Levy M, Cassina P, Barbeito L, Beckman JS. P2X7 receptor-induced death of motor neurons by a peroxynitrite/FAS-de- pendent pathway. J Neurochem. 2013; 126(3): 382-388. 47. Apolloni S, Parisi C, Pesaresi MG et al. The NADPH oxidase pathway is dysregulated by the P2X7 receptor in the SOD1-G93A mi- croglia model of amyotrophic lateral sclero- sis. J Immunol. 2013; 190(10): 5187-5195. 48. Fabbrizio P, Amadio S, Apolloni S, Volonte C. P2X7 receptor activation modulates autopha- gy in sod1-g93a mouse microglia. Front Cell Neurosci. 2017; 11: 249. 49. Ruiz-Ruiz C, García-Magro N, Negredo P et al. Chronic administration of P2X7 receptor antagonist JNJ-47965567 delays disease onset and progression, and improves motor perfor- mance in ALS SOD1(G93A) female mice. Dis Model Mech. 2020; 13(10). CONFLICT OF INTEREST STATEMENT The authors of this article declare that they have no conflict of interest with respect to what is expressed in this work. If you want to quote our article: Fernández A, Gandía L, García AG. Amyotrophic lateral sclerosis is not only a motor neuron disease: impact of the sympathoa- drenal axis. An RANM. 2022;139(01): 78– 87. DOI: 10.32440/ ar.2022.139.01. rev06