Anales de la RANM

138 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 MELATONINA Y COVID-19 Fernández Tresguerres JA, et al. An RANM. 2022;139(02): 135 - 139 La gran cantidad de información importante de que disponemos a propósito de los efectos benefi- ciosos de la melatonina en la enfermedad por SARS COV 2 y que hemos mencionado a lo largo de este trabajo unido a la ausencia de efectos secundarios hacen a la melatonina un excelente candidato para el tratamiento del COVID19. 1. Cardinali D, Brusco L, Cutrera R. Ritmos bio- lógicos. En: Tresguerres JAF, Aguilar Benítez de Lugo E, Devesa Múgica J, Moreno Esteban B, eds. Tratado de endocrinología básica y clí- nica. Madrid: Síntesis; 2000, p. 163-189. 2. Reiter RJ. Melatonin: Clinical relevance: Best Pract Res Clin Endocrinol Metab. 2003; 17: 273-285. 3. Acuña Castroviejo D, Escames G. Melatonina. En: Tresguerres JAF, ed. Fisiologia humana. New York: Mc Graw Hill Interamericana; 2020. 4. Golombek D Cardinali D. Ritmos circadianos. En: Tresguerres JAF, ed. Fisiologia humana. 5ª ed. New York: Mc Graw Hill; 2020. 5. Ianas O, Olinescu R, Badescu I. Melatonin in- volvement in oxidative processes. Endocrino- logie. 1991; 29: 147-153. 6. Tan D, Chen L, Poeggeler B, Manchester L, Re- iter R. Melatonin: a potent, endogenous hydro- xyl radical scavenger. Endocr J.1993; 1: 60-87. 7. Reiter RJ, Tan D, Kim SJ et al. Augmentation of indices of oxidative damage in life-long me- latonin-deficient rats. Mech Ageing Dev. 1999; 110: 157-173. 8. Reiter RJ, D X Tan, S Burkhardt. Reactive oxygen and nitrogen species and cellular and organismal decline: Amelioration with melato- nin. Mech Ageing Dev. 2002; 123: 1007-1019. 9. Kireev RA, Tresguerres AC, García C et al. Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomized female rats. Biogerontology. 2010; 11(2): 229-243. 10. Kireev RA, Tresguerres AF, Vara E, Arizna- varreta C, Tresguerres JA. Effect of chronic treatments with GH, melatonin, estrogens and phytoestrogens on oxidative stress parameters in liver from aged female rats. Biogerontology. 2007; 8(5): 469-482. 11. Kireev RA, Bitoun S, Vara E, Tresguerres AF. Melatonin treatment protects steatotic liver after ischemia/reperfusion by diminishing inflammation, oxidative stress and apoptosis. Clinical Nutrition. 2013; 32: S45-S46. 12. Kennaway DJ, Lushington K, Dawson D, Lack L, van den Heuvel C, Rogers N. Urinary 6-sul- fatoxymelatonin excretion and aging: New re- sults and a critical review of the literature. J Pineal Res. 1999; 27(4): 210-220. 13. Magri F, Sarra S, Cinchetti W, V et al. Qua- litative and quantitative changes of melatonin levels in physiological and pathological aging and in centenarians. J Pineal Res. 2004; 36(4): 256-261. 14. Forman K, Vara E, García C et al. Beneficial effects of melatonin treatment on the cardiolo- gical alterations in a murine model of accele- rated aging. J Pineal Res. 2010; 49(3): 312-320. 15. Paredes SD, Forman KA, García C, Vara E, Es- cames G, Tresguerres JA. Protective actions of melatonin and growth hormone on the aged cardiovascular system. Horm Mol Biol Clin In- vestig. 2014; 18(2): 79-88. 16. Puig A, Rancan L, Paredes SD et al. Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence- accelerated mice model. Exp Gerontol. 2016; 75: 1-7. 17. Cuesta S, Kireev R, García C et al. Benefi- cial effect of melatonin treatment on inflam- mation, apoptosis and oxidative stress on pan- creas of a senescence accelerated mice model. Mech Ageing Dev. 2011; 132(11-12): 573-582. 18. Forman K, Vara E, García C et al. Influence of aging and growth hormone on different mem- bers of the NFkB family and IkB expression in the heart from a murine model of senescence- accelerated aging. Exp Gerontol. 2016; 73: 114-120. 19. Heimberg H, Heremans Y, Jobin C et al. In- hibition of cytokine-induced NF-kappaB ac- tivation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes. 2001; 50(10): 2219-2224. 20. Tresguerres JAF, Kireev R, Forman K, Cuesta S, Tresguerres AF, Vara E. Effect of chronic melatonin administration on several physio- logical parameters from old wistar rats and Samp8 mice. Current Aging Science. 2012; 5(3): 240-251. 21. De la Fuente M, Baeza I, Guayerbas N et al. Changes with ageing in several leukocyte functions of male and female rats. Biogeronto- logy. 2004; 5(6): 389-400. 22. Malaguarnera L, Ferlito L, Imbesi RM et al. Immunosenescence: a review. Arch Gerontol Geriatr. 2001; 32(1): 1-14. 23. Huang C, Wang Y, Li X et al. Clinical features of patients infected with 2019 novel coronavi- rus in Wuhan, China, Lancet. 2020;395(10223): 497-506. https://doi.org/10.1016/S0140- 6736(20)30183-5 24. Chen N, Zhou M, Dong X et al. Epidemio- logical and clinical characteristics of 99 ca- ses of 2019 novel coronavirus pneumonia in Wuhan,China: a descriptive study. Lancet. 2020; 395: 507-513. https://doi.org/10.1016/ S0140-6736(20)30211-7 25. Cardinali DP. High doses of melatonin as a potential therapeutic tool for the neurologic sequels of covid-19 infection. Melatonin Res. 2020; 3: 311-317. 26. Reiter RJ, Sharma R Ma Q et al. Plasticity of glu- cose metabolism in activated immune cells: Ad- vantages for melatonin inhibition of COVID-19 disease. Melatonin Res. 2020; 3: 362-379. 27. Zhang R, Wang X, Ni L et al. COVID-19: Me- CONCLUSIONES BIBLIOGRAFÍA