Anales de la RANM

20 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 ACCIONES PROTECTORAS Y REPARADORAS TISULARES DEL CBD Fernández-Tresguerres Hernández JA, et al. An RANM. 2024;141(01): 12 - 20 45. Juknat A, Pietr M, Kozela E et al. Microarray and pathway analysis reveal distinct mecha- nisms underlying cannabinoid-mediated mo- dulation of lps-induced activation of BV-2 microglial cells. PLoS One. 2013; 8: e61462. doi:10.1371/journal.pone.0061462. 46. Rajesh M, Mukhopadhyay P, Bátkai S et al. Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol. 2010; 56: 2115-2125. doi:10.1016/j.jacc.2010.07.033. 47. Ayala A, Muñoz MF, Argüelles S. Lipid peroxi- dation: Production, metabolism, and signaling mechanisms of malondialdehyde and 4-Hydro- xy-2-Nonenal. Oxid Med Cell Longev. 2014; 2014: 360438. doi:10.1155/2014/360438. 48. Milne GL, Yin H, Hardy KD, Davies SS, Ro- berts LJ. Isoprostane generation and function. Chem Rev. 2011; 111: 5973-5996. doi:10.1021/ cr200160h. 49. Łuczaj W, Gęgotek A, Skrzydlewska E. Antioxi- dants and HNE in redox homeostasis. Free Ra- dic Biol Med. 2017; 111: 87-101. doi:10.1016/j. freeradbiomed.2016.11.033. 50. Środa-Pomianek K, Michalak K, Świątek P, Poła A, Palko-Łabuz A, Wesołowska O. Increa- sed lipid peroxidation, apoptosis and selective cytotoxicity in colon cancer cell line lovo and its doxorubicin-resistant subline lovo/dx in the presence of newly synthesized phenothiazine derivatives. Biomed Pharmacother. 2018; 106: 624-636. doi:10.1016/j.biopha.2018.06.170. 51. Sottero B, Rossin D, Poli G, Biasi F. Lipid oxi- dation products in the pathogenesis of inflam- mation-related gut diseases. Curr Med Chem. 2018; 25: 1311-1326. doi:10.2174/0929867324 666170619104105. 52. Ibeas Bih C, Chen T, Nunn AV, Bazelot M, Da- llas M, Whalley BJ. Molecular targets of can- nabidiol in neurological disorders. Neurothe- rapeutics. 2015; 12(4): 699-730. doi:10.1007/ s13311-015-0377-3. 53. Pollack M, Phaneuf S, Dirks A, Leeu- wenburgh C. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Ann N Y Acad Sci. 2002; 959: 93-107. doi:10.1111/j.1749-6632.2002.tb02086.x. 54. Puig Á, Rancan L, Paredes SD et al. Melatonin decreases the expression of inflammation and apoptosis markers in the lung of a senescence- accelerated mice model. Exp Gerontol. 2016; 75: 1-7. doi:10.1016/j.exger.2015.11.021. 55. Acuña-Castroviejo D, Carretero M, Doerrier C et al. Melatonin protects lung mitochondria from aging. Age (Dordr). 2012; 34: 681-692. doi:10.1007/s11357-011-9267-8. Si desea citar nuestro artículo: Fernández-Tresguerres Hernández JA, Linillos-Pradillo B, Pa- redes SD, Centeno J, Díaz-Del Cerro E, De la Fuente M, Vara E, Rancan L. Acciones protectoras y reparadoras tisulares del CBD (cannabidiol) y efectos inmunitarios. An RANM. 2024;141(01): 12–20. DOI: 10.32440/ar.2024.141.01.rev01