Anales de la RANM

132 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 THE IMPACT OF MIGRATION IN FIRST-EPISODE PSYCHOSIS López Otega A et al. An RANM. 2024;141(02): 126 - 133 With regards to sex, previous studies found men to experience more negative symptoms than women, regardless of migrant status (24). Our results were as expected, they support that these sex differences in clinical presentation are preserved among migrants. Sex-specific stressors of migration have been explored in previous literature. Prior research suggests that men experience more migration- related stress and discrimination (29). This, combined with traditional gender roles in which men are expected to be strong and in control, may make it more difficult for men to seek help (30). All this can lead to a greater severity in the clinical presentation at diagnosis, with greater negative symptoms. Strengths and limitations To the best of our knowledge, this is the first and largest comparative study between migrants and non-migrants with FEP in Spain regarding their clinical presentation at the time of admission in our clinical services. Our study was derived form a large representative multi-centre sample in the autono- mous community of Madrid. It includes different ethnic groups beyond the North-African, which had been the most studied migration group in our country to date. All relevant information was collected using validated instruments and standardised data entry to minimise collection bias across sites. However, there are several limitations in this study. First, the total sample for the main study cohort comprised 417 participants, however our analyses were conducted on a smaller sample (N=363) due to incomplete data at baseline. Although the sample size is smaller than the original recruitment, it remains sufficiently large to ensure adequate statistical power for producing reliable results. Second, the presence of childhood adversities were rated using a retros- pective self-report questionnaire, and therefore the results should be approached with caution (31). The choice of instrument is justified since reports of childhood adversity obtained retrospectively from people with psychotic disorders are stable over time (32). Additionally, it has been qualitatively reclassi- fied into 3 groups, leading to a loss of information. Our recoding was made based on previous articles (33). Finally, there are factors that may affect clinical presentation that were not considered in the study, such as substance use, family psychiatric history or duration of untreated psychosis. It would be interes- ting to further explore other factors, such as those mentioned above, that may influence the clinical presentation of psychosis in migrants and to gain a more complete picture. CONCLUSION The migration experience has an impact on the clinical presentation of first psychotic episodes in first-generation migrants. In our study, first-genera- tion migrants, particularly migrant men, experienced more negative symptoms than natives (i.e. non migrants or second-generation migrants) at baseline. In line with the above, the migratory condition may be considered when assessing subjects with FEP, as this will help to characterise the pathology precisely and provide personalized clinical treatments. CONFLICT OF INTEREST STATEMENT Dr. Arango has been a consultant to or has received honoraria or grants from Abbot, Acadia, Ambrosetti, Angelini, Biogen, Boehringer, Gedeon Richter, Janssen Cilag, Lundbeck, Medscape, Menarini, Minerva, Otsuka, Pfizer, Roche, Sage, Servier, Shire, Schering Plough, Sumitomo Dainippon Pharma, Sunovion, Takeda and Teva. Dr Arango has received support by the Spanish Ministry of Science and Innovation, Instituto de Salud Carlos III (ISCIII), co-financed by the European Union, ERDF Funds from the European Commission, “A way of making Europe”, financed by the European Union - NextGenerationEU (PMP21 /00051), PI19/01024. PI22/01824 CIBERSAM, Madrid Regional Government (B2017/BMD-3740 AGES-CM-2), European Union Structural Funds, European Union Seventh Framework Program, European Union H2020 Program under the Innova- tive Medicines Initiative 2 Joint Undertaking: Project PRISM-2 (Grant agreement No.101034377), Project AIMS-2-TRIALS (Grant agreement No 777394), Horizon Europe, the National Institute of Mental Health of the National Institutes of Health under Award Number 1U01MH124639-01 (Project ProNET) and Award Number 5P50MH115846-03 (project FEP-CAUSAL), Fundación Familia Alonso, and Fundación Alicia Koplowitz. REFERENCES 1. Interactive World Migration Report 2022 [In- ternet]. 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