Anales de la RANM

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Inflammation and immunity in schizophrenia: Implications for pathophysiology and treatment. Lancet Psychiat. 2015; 2: 258-270. 10. Sullivan PF, Daly MJ, O'Donovan M. Gene- tic architectures of psychiatric disorders: the emerging picture and its implications. Nat Rev Genet. 2012; 13(8): 537-551. 11. Schizophrenia Working Group of the Psychia- tric Genomics Consortium. Biological insights from 108 schizophrenia-associated genetic loci. Nature. 2014; 511(7510): 421-427. 12. Zubin J, Spring B. Vulnerability: a new view of schizophrenia. J Abnorm Psychol. 1977; 86(2): 103-126. 13. Arango C, Dragioti E, Solmi M et al. Risk and protective factors for mental disorders be- yond genetics: an evidence-based atlas. World Psychiatry. 2021; 20(3): 417-436. 14. Guerrin CGJ, Doorduin J, Sommer IE, de Vries EFJ. The dual hit hypothesis of schizophre- nia: Evidence from animal models. Neurosci Biobehav Rev. 2021; 131: 1150-1168. 15. Olivenza R, Moro MA, Lizasoain I et al. Chro- nic stress induces the expression of inducible nitric oxide synthase in rat brain cortex. J Neurochem. 2000; 74(2): 785-791. 16. Madrigal JL, Olivenza R, Moro MA et al. Glu- tathione depletion, lipid peroxidation and mi- tochondrial dysfunction are induced by chro- nic stress in rat brain. Neuropsychopharmacol. 2001; 24(4): 420-429. 17. Madrigal JL, Moro MA, Lizasoain I et al. Indu- cible nitric oxide synthase expression in brain cortex after acute restraint stress is regulated by nuclear factor kappaB-mediated mecha- nisms. J Neurochem. 2001; 76(2): 532-538. 18. Munhoz C, Madrigal JL, García-Bueno B et al. TNF-alpha accounts for short-term persis- tence of oxidative status in rat brain after two weeks of repeated stress. Eur J Neurosci. 2004; 20(4): 1125-1130. 19. MacDowell KS, Munarriz-Cuezva E, Caso JR et al. Paliperidone reverts Toll-like receptor 3 signaling pathway activation and cognitive de- ficits in a maternal immune activation mouse model of schizophrenia. 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Stress-induced neuroinflammation: Role of the Toll-like receptor-4 pathway. Biol Psychiatry. 2013; 73(1): 32-43. 25. García Bueno B, Caso JR, Madrigal JL, Leza JC. Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases. Neu- rosci Biobehav Rev. 2016; 64: 134-147. 26. Bris ÁG, MacDowell KS, Ulecia-Morón C et al. Differential regulation of innate immune system in frontal cortex and hippocampus in a "double-hit" neurodevelopmental model in rats. Neurotherapeutics. 2024; 21(1): e00300. 27. García-Bueno B, Madrigal JL, Lizasoain I, Moro MA, Lorenzo P, Leza JC. Peroxisome prolife- rator-activated receptor gamma activation de- creases neuroinflammation in brain after stress in rats. Biol Psychiatry. 2005; 57(8): 885-894. 28. Martín-Hernández D, Martínez M, Robledo- Montaña J et al. Neuroinflammation related to the blood-brain barrier and sphingosine- 1-phosphate in a pre-clinical model of perio- dontal diseases and depression in rats. J Clin Periodontol. 2023; 50(5): 642-656. 29. Miyata S. New aspects in fenestrated capillary and tissue dynamics in the sensory circumven- tricular organs of adult brains. Front Neurosci. 2015; 9: 390. doi: 10.3389/fnins.2015.00390. 30. Vargas-Caraveo A, Sayd A, Maus SR et al. Lipo- polysaccharide enters the rat brain by a lipopro- tein-mediated transport mechanism in physio- logical conditions. Sci Rep. 2017; 7(1): 13113. 31. Ponferrada A, Caso JR, Alou L et al. The role of PPARgamma on restoration of colonic ho- meostasis after experimental stress-induced in- flammation and dysfunction. Gastroenterology. 2007; 132(5): 1791-803. 32. Noll R. The blood of the insane. Hist Psychiatr. 2006; 17(4): 395-418. 33. Zulfic Z, Weickert CS, Weickert TW, Liu D, Myles N, Galletly C. Neutrophil-lymphocyte ratio: a simple, accessible measure of inflam- mation, morbidity and prognosis in psychiatric disorders? Australas Psychiatry. 2020; 28(4): 454-458.