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141 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 FISIOPATOLOGÍA INFLAMATORIA EN PSICOSIS Leza JC An RANM. 2024;141(02): 134 - 141 34. Bioque M, Matias-Martins AC, Llorca-Bofí V et al. Neutrophil to lymphocyte ratio in patients with a first episode of psychosis: a two-year longitudinal follow-up study. Schizophr Bull. 2022; 48(6): 1327-1335. 35. Kappelmann N, Khandaker GM, Dal H, Stochl J et al. Systemic inflammation and intelligen- ce in early adulthood and subsequent risk of schizophrenia and other non-affective psycho- ses: a longitudinal cohort and co-relative study. Psychol Med. 2019; 49(2): 295-302. 36. Miller BJ, Buckley P, Seabolt W, Mellor A, Kirk- patrick B. Meta-analysis of cytokine alterations in schizophrenia: Clinical status and antip- sychotic effects. Biol Psychiatry. 2011; 70(7): 663-671. 37. Wang AK, Miller BJ. Meta-analysis of cerebros- pinal fluid cytokine and tryptophan catabolite alterations in psychiatric patients: Compari- sons between schizophrenia, bipolar disorder, and depression. Schizophr Bull. 2018; 44(1): 75-83. doi: 10.1093/schbul/sbx035. 38. Khandaker GM, Pearson RM, Zammit S, Lewis G, Jones PB. Association of serum interleukin 6 and C-reactive protein in childhood with depression and psychosis in young adult life: a population-based longitudinal study. JAMA Psychiatry. 2014; 71(10): 1121-1128. 39. Wium-Andersen MK, Ørsted DD, Nordestgaard BG. Elevated C-reactive protein associated with late- and very-late-onset schizophrenia in the general population: a prospective study. Schi- zophr Bull. 2014; 40(5): 1117-1127. 40. Song XQ, Lv LX, Li WQ, Hao YH, Zhao JP. The interaction of nuclear factor-kappa B and cyto- kines is associated with schizophrenia. Biol Psychiatry. 2009; 65(6): 481-488. 41. Martínez-Gras I, Pérez-Nievas BG, García-Bue- no B et al. The anti-inflammatory prostaglandin 15d-PGJ2 and its nuclear receptor PPARgamma are decreased in schizophrenia. Schizophr Res. 2011; 128(1-3): 15-22. 42. García-Bueno B, Bioque M, MacDowell KS et al. Pro-/anti-inflammatory dysregulation in pa- tients with first episode of psychosis: Toward an integrative inflammatory hypothesis of schizo- phrenia. Schizophr Bull. 2014; 40(2): 376-387. 43. García-Bueno B, Bioque M, MacDowell KS et al. Pro-/antiinflammatory dysregulation in early psychosis: Results from a 1-year follow- up study. Int J Neuropsychopharmacol. 2014; 18(2): pyu037. 44. Cabrera B, Bioque M, Penadés R et al. Cog- nition and psychopathology in first-episode psychosis: Are they related to inflammation? Psychol Med. 2016; 46(10): 2133-2144. 45. Martínez-Cengotitabengoa M, Mac-Dowell KS, Leza JC et al. Cognitive impairment is related to oxidative stress and chemokine le- vels in first psychotic episodes. Schizophr Res. 2012; 137(1-3): 66-72. 46. Wang AK, Miller BJ. Meta-analysis of cere- brospinal fluid cytokine and tryptophan ca- tabolite alterations in psychiatric patients: Comparisons between schizophrenia, bipo- lar disorder, and depression. Schizophr Bull. 2018; 44(1): 75-83. 47. García-Bueno B, Gassó P, MacDowell KS et al. Evidence of activation of the Toll-like recep- tor-4 proinflammatory pathway in patients with schizophrenia. J Psychiatry Neurosci. 2016; 41(3): E46-55. 48. Ishida I, Ogura J, Aizawa E, Ota M, Hidese S, Yomogida Y, et al. Gut permeability and its clinical relevance in schizophrenia. Neurop- sychopharmacol Rep. 2022 Mar;42(1):70-76. 49. Wang C, Zhang T, He L, Fu JY, Deng HX, Xue XL, et al. Bacterial Translocation Associates With Aggression in Schizophrenia Inpatients. Front Syst Neurosci. 2021 Sep 29;15:704069. 50. Çakici N, van Beveren NJM, Judge-Hundal G, Koola MM, Sommer IEC. An update on the effi- cacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis. Psychol Med. 2019 Oct;49(14):2307-2319. Si desea citar nuestro artículo: Leza JC. Fisiopatología inflamatoria en psicosis. An RANM. 2024;141(02): 134–141. DOI: 10.32440/ar.2024.141.02. rev 04