Anales de la RANM
148 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 DEL ÓXIDO NÍTRICO A LA ACCION ANTIINFLAMATORIA DE LA NITROGLICERINA Berrazueta Fernández JR An RANM. 2025;142(02): 140 - 149 8. Balard JM. Premier memoire sur l'alcool amylique. Ann Chim Phys 1844;12: 294-330. 9. Feehlisch M, Noack EA. Correlation between nitnc oxide formation during degradation of organic nitrates and activation of guanylate cyclase. Eur J Pharmacol 1987;139:19-30. 10. Duarte ID, Lorenzetti BB, Ferreira SH. Peri- pheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Eur J Pharmacol. 1990 ;186(2-3):289-293. doi: 10.1016/0014- 2999(90)90446-d. PMID: 1981187.. 11. Ialenti A, Ianaro A, Moncada S. Di Rosa M. Modulation of acute inflammation by endoge- nous nitric oxide. Eur J Pharm 1992; 211:177- 182. 12. Berrazueta JR, López Jaramillo P, Moncada S. El óxido nítrico: de vasodilatador endógeno a mediador biológico. Rev Esp Cardiol 1990; 43: 421-431. 13. Berrazueta JR, Ochoteco J, Poveda JJ, et al. Tratamiento transcutáneo de la tromboflebitis superficial con el donador exógeno de óxi- do nítrico: Nitroglicerina. Rev Esp Cardiol 1991;44:424-426, 14. Berrazueta JR, Poveda JJ, Ochoteco J, et al. The anti-inflammatory and analgesic action of transdermal glyceryltrinitrate in the treatment of infusion-related thrombophlebitis. Post- grad Med J. 1993;69(807):37-40. doi: 10.1136/ pgmj.69.807.37. PMID: 8383319; PMCID: PMC2399598 15. Berrazueta JR, Fleitas M, Salas E, et al. Lo- cal transdermal glyceryl trinitrate has an antiinflammatory action on thrombophle- bitis induced by sclerosis of leg varico- se veins. Angiology. 1994;45:347-351. doi: 10.1177/000331979404500503. PMID: 8172381 16. Berrazueta JR, Salas E, Ochoteco A, Poveda JJ, Sánchez de Vega MJ. Acción analgésica peri- férica del donador de óxido nítrico: Nitrogli- cerina. Estudio control frente a placebo de la acción de la Nitroglicerina transdérmica sobre la sensibilidad dolorosa del antebrazo. Rev Esp Cardiol. 1993; 46:10-14. 17. Ferreira SH, Lorenzetti BB, Faccioli LH. Bloc- kade of hyperalgesia and neurogenic oede- ma by topical application of nitroglycerin. Eur J Pharmacol. 1992 ;217(2-3):207-209. doi: 10.1016/0014-2999(92)90871-z. PMID: 1425939. 18. PATENTE. Utilización de los nitrovasodila- tadores en la preparación de medicamentos antiinflamatorios y analgésicos de uso tópico. Solicitante José Ramón de Berrazueta Fernán- dez. N._ de publicación: ES 2 059 264. Núme- ro de solicitud: 920223. Fecha de publicación de la solicitud: 01.11.94 Prioridad 1992-11-05. Anticipated expiration 2012-11-05 Priority to ES9202231A. 1992-11-05 1995-06-16 Berra- zueta Fernandez JoseRamon USE OF NITRO- VASODILATORS IN THE PREPARATION OF ANTI INFLAMMATORY AND ANALGESIC MEDICINES FOR TOPICAL USE. 19. Berrazueta JR, Riestra A, Salas E, et al. Aqua- genic pruritus response to the exogenous nitric oxide donor, transdermal nitroglycerin. Int J Dermatol. 1994; 33:752-753. doi: 10.1111/ j.1365-4362.1994.tb01528.x. PMID: 8002150. 20. Di Nisio M, Peinemann F, Porreca E, Rutjes AW. Treatment for superficial infusion throm- bophlebitis of the upper extremity. Cochrane Database Syst Rev. 2015;2015(11):CD011015. doi: 10.1002/14651858.CD011015.pub2. PMID: 26588711; PMCID: PMC6885032. 21. Almenar L, Hernández M, Gimeno JV, Palencia M, Algarra F. Heparinoides frente a nitrogli- cerina en el tratamiento de las flebitis superfi- ciales [Heparinoids versus nitroglycerin in the treatment of superficial phlebitis]. Rev Clin Esp. 1993;193(5):229-231. Spanish. PMID: 8256008. 22. Berrazueta JR, Sampedro I, Garcia-Unzue- ta MT, Llorca J, Bustamante M, Amado JA. Effect of transdermal nitroglycerin on in- flammatory mediators in patients with peri- pheral atherosclerotic vascular disease. Am Heart J. 2003;146(4):E14. doi: 10.1016/S0002- 8703(03)00391-0. PMID: 14564337 23. Matsui A, Murakami M, Hata S, et al. The Efficacy of the Transdermal Isosorbide Di- nitrate Patch in Patients With Chronic Limb-Threatening Ischemia. Int J Low Ex- trem Wounds. 2022 ;21(4):477-482. doi: 10.1177/1534734620959515. Epub 2020 Sep 23. PMID: 32962459) 24. McAra S. Effectiveness of glyceryl trinitrate (GTN) vasodilator patches in peripheral arte- rial disease. J Foot Ankle Res 2015;8(Suppl2): P8 http://www.jfootankleres.com /content/8/ S2/ P8) 25. Sushko,K, Litalien C, Ferruccio L et al. To- pical nitroglycerin ointment as salvage the- rapy for peripheral tissue ischemia in new- borns: a systematic review. CMAJ Open 2021; 9 (1) E252-E260; doi: https://doi.org/10.9778/ cmajo.20200129) 26. Wang P, Gu L, Qin Z, Wang Q, Ma J. Effica- cy and safety of topical nitroglycerin in the prevention of mastectomy flap necrosis: a systematic review and meta-analysis. Sci Rep. 2020;10(1):6753. doi: 10.1038/s41598- 020-63721-1. PMID: 32317705; PMCID: PMC7174291. 27. Berrazueta JR, Losada A, Poveda J, et al. Suc- cessful treatment of shoulder pain syndrome due to supraspinatus tendinitis with trans- dermal nitroglycerin. A double blind study. Pain. 1996;66(1):63-67. doi: 10.1016/0304- 3959(96)03021-7. PMID: 8857632 28. Paoloni JA; Appleyard RC; Nelson, J; Murrell GAC. Topical glyceryl trinitrate application in the treatment of chronic supraspinatus ten- dinopathy: a randomized, double-blinded, placebo-controlled clinical trial. Am J Sports Med 2005; 33: 806-813 29. Giner-Pascual, M., Alcanyis-Alberola, M., Querol, F et al. Transdermal nitroglyce- rine treatment of shoulder tendinopathies in patients with spinal cord injuries. Spi- nal Cord .2011;49: 1014–1019. https://doi. org/10.1038/sc.2011.41 30. Cumpston M, Johnston RV, Wengier L, et al. . Topical glyceryl trinitrate for rota- tor cuff disease. 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