Anales de la RANM

149 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 DEL ÓXIDO NÍTRICO A LA ACCION ANTIINFLAMATORIA DE LA NITROGLICERINA Berrazueta Fernández JR An RANM. 2025;142(02): 140 - 149 31. Paoloni JA, Appleyard RC, Nelson J, Murrell GA. Topical nitric oxide application in the treatment of chronic extensor tendinosis at the elbow: a randomized, double-blinded, placebo-controlled clinical trial. Am J Sports Med. 2003;31(6):915- 920. doi: 10.1177/03635465030310062901. PMID: 14623657.) 32. McCulloch C, Hunter MM, Lipp C, Lang E, Ganshorn H, Singh P. Management of Late- ral Epicondylitis Using Transdermal Nitro- glycerin: A Systematic Review. Cureus. 2022; 14(12):e32560. doi: 10.7759/cureus.32560. PMID: 36654592; PMCID: PMC9840472.) 33. Paoloni J, Appleyard RC, Nelson J, Murrell GA, MBBS G. Topical Glyceryl Trinitrate Treatment of Chronic Noninsertional Achilles Tendinopathy : A Randomized, Double-Blind, Placebo-Controlled Trial. J Bone Joint Surg Am 2004;86(5):916-922. 34. Kane TP, Ismail M, Calder JD. Topical glyce- ryl trinitrate and noninsertional Achilles ten- dinopathy: a clinical and cellular investiga- tion. Am J Sports Med 2008; 36:1160–1163. 35. Kirwan PD, Duffy T, French HP. Topical glyce- ryl trinitrate (GTN) and eccentric exercises in the treatment of mid-portion achilles tendi- nopathy (the NEAT trial): a randomised dou- ble-blind placebo-controlled trial.Br J Sports Med 2024;58:1035-1043. 36. Paoloni JA, Murrell GA. Three-year follow up study of topical glyceryl trinitrate treatment of chronic noninsertional Achilles tendinopathy. Foot Ankle Int 2007; 28: 1064–1068. 37. Schaffer MR, Tantry U, Gross SS, Wasserburg HL, Barbul A. Nitric oxide regulates wound healing. J Surg Res 1996;63:23740. 38. Shabanic M, Pulfer SK, Bulgrin JP, Smith DJ. Enhancement of wound repair with a topically applied nitric oxide-releasing polymer. Wound Repair Regul 1996;4:353-362. 39. Murrell GAC. Using nitric oxide to treat ten- dinopathy. Br J Sports Med 2007;41:227–231. doi: 10.1136/bjsm.2006.034447 40. Murrell G A C, Szabo C, Hannafin J A, et al. Modulation of tendon healing by nitric oxide. Inflamm Res 1997:4619–4627 41. Steunebrink M, Zwerver J, Brandsema R, et al. Topical glyceryl trinitrate treatment of chronic patellar tendinopathy: a randomised, double- blind, placebo-controlled clinical trial. Br J Sports Med 2013; 47, 34–39 42. Challoumas D, Pedret C, Biddle M, et al. Ma- nagement of patellar tendinopathy: a syste- matic review and network meta- analysis of randomised studies. BMJ Open Sport & Exer- cise Med 2021;7:e001110. doi:10.1136/ bmj- sem-2021-001110 43. Challoumas D, Kirwan PD, Borysov D,et al. Topical glyceryl trinitrate for the treatment of tendinopathies: a systematic review. Br J Sports Med 2019;53:251–262. 44. Gambito ED, Gonzalez-Suarez CB, Oquiñena TI, Agbayani RB. Evidence on the effective- ness of topical nitroglycerin in the treatment of tendinopathies: a systematic review and meta-analysis. Arch Phys Med Rehabil. 2010;91(8):1291-1305. Si desea citar nuestro artículo: Berrazueta Fernández JR. Del Óxido Nítrico a la accion antiinflamatoria de la Nitroglicerina. 35 años des- pués. An RANM. 2025;142(02): 140– 149. DOI: 10.32440/ ar.2025.142.02. rev04