Anales de la RANM

254 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 NUEVOS FÁRMACOS DONADORES DE ÓXIDO NÍTRICO Berrazueta Fernández JR An RANM. 2025;142(03): 246 - 254 26. Ongini E, Impagnatiello F, Bonazzi A, Guzzetta M, Govoni M, Monopoli A et al. Nitric oxide (NO)-releasing statin derivatives, a class of drugs showing enhanced antiproliferative and antiinflammatory properties. Proc Natl Acad Sci USA 2004; 101: 8497–8502. 27. Garthwaite, J. From synaptically localized to volume transmission by nitric oxide. The Jour- nal of Physiology. 2016; 594: 9 - 18. 28. Wisor, J. P., Gerashchenko, D., & Kilduff, T. S. (2011). Sleep active neuronal niitric oxide synthase positive cells of the cerebral cortex: a. local regulator of sleep?. Current Topics in Me- dicinal Chemistry. 2011; 11: 2483 -2489. 29. Yu, X., Li, W., Ma, Y., Tossell, K., Harris, J. J., Harding, E. C. Wisden, W. GABA and glutamate neurons in the VTA regulate sleep and Wakeful- ness. Nature Neuroscience 2019; 22 : 106 – 119. 30. Funk, O. H., & Kwan, K. Y. (2014). Nitric oxide signaling in the development and evolution of language and cognitive circuits. Neuroscience Research 2014; 86 : 77 – 87. 31. Hesse, R., Lausser, L., Gummert, P. et al. Redu- ced cGMP levels in CSF of AD patients correla- te with severity of dementia and current depres- sion. Alz Res Therapy 2017; 9, 17. https://doi. org/10.1186/s13195-017-0245-y 32. Hollas MA, Ben Aissa M , Lee SH, Gordon- Blake JM, Thatcher GRJ. Pharmacological ma- nipulation of cGMP and NO/cGMP in CNS drug discovery. Nitric. Oxide 2019; 82:59-74. https://doi.org/10.1016/j.niox.2018.10.006 33. Mahendiran T, Bouisset F, Tonino P, et aL. Ti- tanium-nitride-oxide-coated vs. drug-eluting stents in acute coronary syndromes: an indi- vidual patient data meta-analysis, European Heart Journal, 2025; 46: 2092-2100. https://doi. org/10.1093/eurheartj/ehaf098 34. Chen, Y., Gao, P., Huang, L. et al. A tough ni- tric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent. Natu- re communications, 2021, vol. 12, no 1, p. 7079. 35. Meunier, M., Yammine, A., Bettaieb, A. et al. Nitroglycerin: a comprehensive review in cancer therapy. Cell Death Dis. 2023; 14, 323. https://doi.org/10.1038/s41419-023-05838-5 36. Huang JB, Chen ZR, Yang SL, Hong FF. Ni- tric Oxide Synthases in Rheumatoid Arthritis. Molecules. 2023; ;28:4414. doi: 10.3390/mo- lecules28114414. PMID: 37298893; PMCID: PMC10254167. Si desea citar nuestro artículo: Berrazueta Fernández JR. Nuevos fármacos donadores de Óxido Nítrico desarrollados 35 años después de la des- cripción de la accion antiinflamatoria de la Nitroglice- rina. An RANM. 2025;142(03): 246– 254. DOI: 10.32440/ ar.2025.142.03. rev03