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173 A N A L E S R A N M R E V I S T A F U N D A D A E N 1 8 7 9 DATOS Y ALGORITMOS QUE CURAN Dopazo J An RANM. 2026;143(02): 167 - 173 19. Ostaszewski M, Niarakis A, Mazein A, et al. COVID19 Disease Map, a computational knowledge repository of virus-host interac- tion mechanisms. Molecular systems biolo- gy. 2021;17(10). https://doi.org/10.15252/ MSB.202110387 20. Rian K, Esteban-Medina M, Hidalgo MR, et al. Mechanistic modeling of the SARS-CoV-2 disease map. BioData Mining. 2021;14(1). https://doi.org/10.1186/s13040-021-00234-1 21. Loucera C, Peña-Chilet M, Esteban-Medina M, et al. Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospi- talized Andalusian patients. Scientific Reports 2021 11:1. 2021;11(1): 23380-. https://doi. org/10.1038/s41598-021-02701-5 22. Loucera C, Carmona R, Esteban-Medina M, et al. Real-world evidence with a retrospec- tive cohort of 15,968 COVID-19 hospitalized patients suggests 21 new effective treatments. Virology Journal 2023 20:1. 2023;20(1): 226-. https://doi.org/10.1186/S12985-023-02195-9 23. Esteban M, Peña-Chilet M, Loucera C, Dopa- zo J. Exploring the druggable space around the Fanconi anemia pathway using machine lear- ning and mechanistic models. bioRxiv. 2019. https://doi.org/10.1101/647735. 24. Esteban-Medina M, Loucera C, Rian K, et al. The mechanistic functional landscape of re- tinitis pigmentosa: a machine learning-dri- ven approach to therapeutic target discovery. Journal of Translational Medicine 2024 22:1. 2024;22(1): 139-. https://doi.org/10.1186/ S12967-024-04911-7 25. Esteban-Medina M, de la Oliva Roque VM, Herráiz-Gil S, Peña-Chilet M, Dopazo J, Lou- cera C. drexml: A command line tool and Python package for drug repurposing. Compu- tational and Structural Biotechnology Journal. 2024;23: 1129–1143 26. Box GEP. Science and Statistics. Journal of the American Statistical Association. 1976;71(356): 791–799. https://doi.org/10.108 0/01621459.1976.10480949 Si desea citar nuestro artículo: Dopazo J. Datos y algoritmos que nos permiten entender la enfer- medad y ayudan a curarla. An RANM. 2026;143(02): 167– 173. DOI: 10.32440/ar.2026.143.02.r ev04